Responsive and activable nanomedicines for remodeling the tumor microenvironment Yinlong Zhang, Xuexiang Han, Guangjun Nie Published: 2020-12-10 DOI: 10.1038/s41596-020-00421-0 tumor microenvironment nanomedicines platelets stellate cells drug delivery AI 解读 浏览 1687 PDFMetadata 暂无数据 推荐阅读 Nature Protocols Protocols IO Current Protocols High-throughput single-cell transcriptomics of bacteria using combinatorial barcoding Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis An unbiased method for evaluating the genome-wide specificity of base editors in rice Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH Designing and executing prime editing experiments in mammalian cells Design and application of the transformer base editor in mammalian cells and mice Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting Routine culture and study of adult human brain cells from neurosurgical specimens Simultaneously measuring the methylation of parent and daughter strands of replicated DNA at the single-molecule level by Hammer-seq Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging 查看全部 Mapping CGRP-IR innervation of male mice stomach with Neurolucida 360 CHOP TMC Single Cell Multiome ATAC + Gene Expression HuBMAP Children's Hospital of Philadelphia TMC Cloning individual AAV capsid variants ASAPCRN Cell culture Targeted ExSeq -- In Situ Sequencing (Illumina Chemistry) expansion microscopy in situ sequencing expansion sequencing targeted ExSeq ExSeq spatial transcriptomics spatial omics spatially resolved transcriptomics Well-tempered Metadynamics protocol Synaptic immunohistochemistry - wholemount via acetone permeabilization Recombinant αS purification Protocol ASAPCRN protocols.io academic and non-profit contract Panicle Ratio Network: A high-throughput dynamic phenotype recognition model based on ultra-high-definition unmanned aerial vehicle images for rice panicle analysis in fields 查看全部 Microglial Phagocytosis/Cell Health High-Content Assay cell health high-content analysis microglia phagocytosis quantitative phenotypic assay Design and Construction of a Designed Ankyrin Repeat Protein (DARPin) Display Library DARPin designed ankyrin repeat protein DNA library construction next-generation sequencing protein binder protein display Cap 1 Messenger RNA Synthesis with Co-transcriptional CleanCap® Analog by In Vitro Transcription cap 1 cap analog CleanCap in vitro transcription messenger RNA Working with Worms: Caenorhabditis elegans as a Model Organism C. elegans education genetics overview A Computational Workflow for Analysis of 3′ Tag-Seq Data computational pipeline differential gene expression RNA sequencing 3′ Tag-Seq STARR-seq and UMI-STARR-seq: Assessing Enhancer Activities for Genome-Wide-, High-, and Low-Complexity Candidate Libraries cis-regulatory element enhancer functional genomics gene expression gene regulation massively parallel reporter assay MPRA STARR-seq transcriptional regulation UMI-STARR-seq RNA-Seq Data Analysis: A Practical Guide for Model and Non-Model Organisms assembly differential expression non-model plants plotting reproducibility RNA-seq In Vitro Cultivation of the Syphilis Spirochete Treponema pallidum cell culture in vitro cultivation laboratory growth spirochetes syphilis Treponema pallidum Quantification of GTPase Cycling Rates of GTPases and GTPase:Effector Mixtures Using GTPase Glo Assays Cdc42 GTPase activity GTPase assay GTPase cycling rates GTPase effectors Using EMBL-EBI Services via Web Interface and Programmatically via Web Services bioinformatics resources bioinformatics tools programmatic access REST SOAP web services workflows 查看全部