Probing low-copy-number proteins in single living cells using single-cell plasmonic immunosandwich assays

Jia Liu, Hui He, Dan Xie, Yanrong Wen, Zhen Liu

Published: 2021-06-03 DOI: 10.1038/s41596-021-00547-9

ultrasensitive detection

single-cell analysis

low-copy-number proteins

plasmonic immunosandwich assay

plasmon-enhanced Raman scattering

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Cellular heterogeneity is pervasive and of paramount importance in biology. Single-cell analysis techniques are indispensable for understanding the heterogeneity and functions of cells. Low-copy-number proteins (fewer than 1,000 molecules per cell) perfor
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ACKNOWLEDGMENTS

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Probing low-copy-number proteins in single living cells using single-cell plasmonic immunosandwich assays

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