Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages

Xiangang Huang, Chuang Liu, Na Kong, Yufen Xiao, Arif Yurdagul, Ira Tabas, Wei Tao

Published: 2022-02-03 DOI: 10.1038/s41596-021-00665-4

siRNA nanoparticles

atherosclerosis

macrophages

CaMKIIγ

therapeutic effects

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Macrophages in atherosclerotic lesions promote plaque progression and are an attractive therapeutic target in cardiovascular research. Here we present a protocol for synthesis of small interfering RNA (siRNA) nanoparticles (NP) that target lesional macrop
Introduction
Materials
Procedure
Troubleshooting
Timing
Anticipated results
- Reporting Summary
- References
References
ACKNOWLEDGMENTS

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关键词

siRNA nanoparticles

atherosclerosis

macrophages

CaMKIIγ

therapeutic effects

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