Preparation, construction and high-throughput automated analysis of human brain tissue microarrays for neurodegenerative disease drug development

Malvindar K. Singh-Bains, Nasim F. Mehrabi, Adelie Y. S. Tan, Richard L. M. Faull, Mike Dragunow

Published: 2021-03-18 DOI: 10.1038/s41596-021-00503-7

Drug Discovery

Neurodegenerative Diseases

High-Throughput Analysis

Tissue Microarrays

Automated Platforms

AI 解读

Author Correction: Full-length sequencing of circular DNA viruses and extrachromosomal circular DNA using CIDER-Seq

Generation of heart-forming organoids from human pluripotent stem cells

Design and fabrication of wearable electronic textiles using twisted fiber-based threads

Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo

Chromatin accessibility profiling by ATAC-seq

Deoxyfluorination of phenols for chemoselective18F-labeling of peptides

Author Correction: cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA

Human primordial germ cell-like cells specified from resetting precursors develop in human hindgut organoids

An inexpensive semi-automated sample processing pipeline for cell-free RNA extraction

Application of CHyMErA Cas9-Cas12a combinatorial genome-editing platform for genetic interaction mapping and gene fragment deletion screening

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A major challenge in the treatment of neurodegenerative disorders is the translation of effective therapies from the lab to the clinic. One approach to improve this process is the use of human brain tissue microarray (HBTMA) technology to aid in the disco
Introduction
Materials
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Anticipated results
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ACKNOWLEDGMENTS
ACKNOWLEDGMENTS

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Preparation, construction and high-throughput automated analysis of human brain tissue microarrays for neurodegenerative disease drug development

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