Inverse electron demand Diels–Alder click chemistry for pretargeted PET imaging and radioimmunotherapy

Samantha M. Sarrett, Outi Keinänen, Eric J. Dayts, Guillaume Dewaele-Le Roi, Cindy Rodriguez, Kathryn E. Carnazza, Brian M. Zeglis

Published: 2021-06-13 DOI: 10.1038/s41596-021-00540-2

PET imaging

radioimmunotherapy

pretargeting

Diels–Alder reaction

cancer therapy

AI 解读

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Radiolabeled antibodies have shown promise as tools for both the nuclear imaging and endoradiotherapy of cancer, but the protracted circulation time of radioimmunoconjugates can lead to high radiation doses to healthy tissues. To circumvent this issue, we
Introduction
Materials
Procedure 1: synthesis of Tz-bearing precursors
Procedure 2: preparation of huA33-TCO, radiochemistry and invivo pretargeting experiments
Troubleshooting
Timing
Anticipated results
References
ACKNOWLEDGMENTS
ACKNOWLEDGMENTS

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Inverse electron demand Diels–Alder click chemistry for pretargeted PET imaging and radioimmunotherapy

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