An overview of growth factors as the potential link between psoriasis and metabolic syndrome.
Mateusz Matwiejuk, Adrian Chabowski, Iwona Flisiak, Hanna Myśliwiec
Abstract
Psoriasis
is a chronic, complex, immunologically mediated, systematic disease that can
not only affect the skin but also the joints, and nails. It may coexist with
various other disorders such as depression, psoriatic arthritis, cardiovascular
diseases, diabetes mellitus, and metabolic syndrome. In particular, the
potential link between psoriasis and metabolic syndrome is worthy of an
attention issue. A dysregulated level of growth factors could potentially
contribute to the disturbances of keratinocyte proliferation, inflammation, and
severity of itch. However, the
pathophysiology of psoriasis and its comorbidities, such as metabolic syndrome,
remain incompletely elucidated. Growth factors and their abnormal metabolism may
be the potential link connecting this conditions. Overall, the objective of
this review is to analyze the role of growth factors disturbances in psoriasis
and in metabolic syndrome.
Attachments
Steps
Identification of records. Databases (n = 1) Pubmed
Screening of records
Records screened (n = 1579)
Records excluded (n = 1372 )
No data available
Abstracts
Reports assesed for eligibility (n = 207 )
Reports excluded
Reason 1 (n = 38 ) Duplications
Reason 2 (n = 77 ) Out of scope
Studies included in review (n = 92 )
Records
identified
