Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP

Jendrik Schöppe, Janosch Ehrenmann, Yann Waltenspühl, Andreas Plückthun

Published: 2022-02-08 DOI: 10.1038/s41596-021-00660-9

High-throughput screening

GPCRs

Thermostabilization

Crystallization

LCP

AI 解读

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Structural studies of G-protein-coupled receptors (GPCRs) are often limited by difficulties in obtaining well-diffracting crystals suitable for high-resolution structure determination. During the past decade, crystallization in lipidic cubic phase (LCP) h
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ACKNOWLEDGMENTS

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Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP

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