Reaction screening in multiwell plates: high-throughput optimization of a Buchwald–Hartwig amination

Adam Cook, Roxanne Clément, Stephen G. Newman

Published: 2021-01-10 DOI: 10.1038/s41596-020-00452-7

Buchwald–Hartwig amination

High-throughput screening

Chemical reactions

Microarrays

Gas chromatography

AI 解读

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Chemical space is vast, and chemical reactions involve the complex interplay of multiple variables. As a consequence, reactions can fail for subtle reasons, necessitating screening of conditions. High-throughput experimentation (HTE) techniques enable a m
Introduction
- Experimental design
Materials
Procedure
Troubleshooting
Timing
Anticipated results
References
ACKNOWLEDGMENTS

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Reaction screening in multiwell plates: high-throughput optimization of a Buchwald–Hartwig amination

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