Physical dynamic double-network hydrogels as dressings to facilitate tissue repair

Baolin Guo, Yongping Liang, Ruonan Dong

Published: 2023-09-26 DOI: 10.1038/s41596-023-00878-9

double-network hydrogels

tissue repair

self-healing

wound dressings

bioresponsive properties

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Gurtner, G. C., Werner, S., Barrandon, Y. & Longaker, M. T. Wound repair and regeneration. Nature 453, 314–321 (2008).
Eming, S. A., Martin, P. & Tomic-Canic, M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci. Transl. Med. 6, 265sr266 (2014).
Chen, J. Y. et al. Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing. Acta Biomater. 146, 119–130 (2022).
Yu, R., Yang, Y., He, J., Li, M. & Guo, B. Novel supramolecular self-healing silk fibroin-based hydrogel via host–guest interaction as wound dressing to enhance wound healing. Chem. Eng. J. 417, 128278 (2021).
Zhang, L. W., Liu, M., Zhang, Y. J. & Pei, R. J. Recent progress of highly adhesive hydrogels as wound dressings. Biomacromolecules 21, 3966–3983 (2020).
Blacklow, S. O. et al. Bioinspired mechanically active adhesive dressings to accelerate wound closure. Sci. Adv. 5, eaaw3963 (2019).
Li, M., Liang, Y., Liang, Y., Pan, G. & Guo, B. Injectable stretchable self-healing dual dynamic network hydrogel as adhesive anti-oxidant wound dressing for photothermal clearance of bacteria and promoting wound healing of mrsa infected motion wounds. Chem. Eng. J. 427, 132039 (2022).
Chen, R. M. et al. A bionic cellulose nanofiber-based nanocage wound dressing for NIR-triggered multiple synergistic therapy of tumors and infected wounds. Biomaterials 281, 121330 (2022).
He, J. H., Shi, M. T., Liang, Y. P. & Guo, B. L. Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds. Chem. Eng. J. 394, 124888 (2020).
Zhao, X. et al. Physical double-network hydrogel adhesives with rapid shape adaptability, fast self-healing, antioxidant and nir/ph stimulus-responsiveness for multidrug-resistant bacterial infection and removable wound dressing. Adv. Funct. Mater. 30, 1910748 (2020).
Ding, X. Y. et al. Injectable self-healing hydrogel wound dressing with cysteine-specific on-demand dissolution property based on tandem dynamic covalent bonds. Adv. Funct. Mater. 31, 2011230 (2021).
Zhang, Y. S. & Khademhosseini, A. Advances in engineering hydrogels. Science 356, eaaf3627 (2017).
Qu, J. et al. Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing. Biomaterials 183, 185–199 (2018).
Ghobril, C. & Grinstaff, M. W. The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial. Chem. Soc. Rev. 44, 1820–1835 (2015).
Maleki, A. et al. Multifunctional photoactive hydrogels for wound healing acceleration. ACS Nano 15, 18895–18930 (2021).
Liang, Y. P., He, J. H. & Guo, B. L. Functional hydrogels as wound dressing to enhance wound healing. ACS Nano 15, 12687–12722 (2021).
Konieczynska, M. D. et al. On-demand dissolution of a dendritic hydrogel-based dressing for second-degree burn wounds through thiol-thioester exchange reaction. Angew. Chem. Int. Ed. 55, 9984–9987 (2016).
Cheng, H. et al. Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities. Acta Biomater. 124, 219–232 (2021).
Zhao, X. et al. Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing. Biomaterials 122, 34–47 (2017).
Wu, Y., Wang, L., Guo, B. & Ma, P. X. Injectable biodegradable hydrogels and microgels based on methacrylated poly(ethylene glycol)-co-poly(glycerol sebacate) multi-block copolymers: synthesis, characterization, and cell encapsulation. J. Mater. Chem. B 2, 3674–3685 (2014).
Liang, Y. P., Zhao, X., Hu, T. L., Han, Y. & Guo, B. L. Mussel-inspired, antibacterial, conductive, antioxidant, injectable composite hydrogel wound dressing to promote the regeneration of infected skin. J. Colloid Interface Sci. 556, 514–528 (2019).
Liang, Y. et al. Adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full-thickness skin regeneration during wound healing. Small 15, 1900046 (2019).
Gong, J. P., Katsuyama, Y., Kurokawa, T. & Osada, Y. Double-network hydrogels with extremely high mechanical strength. Adv. Mater. 15, 1155–1158 (2003).
Huang, X. X. et al. Research progress on double-network hydrogels. Mater. Today Commun. 29, 102757 (2021).
Chen, K. W. et al. Entanglement-driven adhesion, self-healing, and high stretchability of double-network peg-based hydrogels. ACS Appl. Mater. Inter. 11, 36458–36468 (2019).
Yang, B. et al. Injectable adhesive self-healing multicross-linked double-network hydrogel facilitates full-thickness skin wound healing. ACS Appl. Mater. Inter. 12, 57782–57797 (2020).
Ahmadian, Z. et al. A hydrogen-bonded extracellular matrix-mimicking bactericidal hydrogel with radical scavenging and hemostatic function for ph-responsive wound healing acceleration. Adv. Healthc. Mater. 10, 2001122 (2021).
Guo, S. et al. Injectable self-healing adhesive chitosan hydrogel with antioxidative, antibacterial, and hemostatic activities for rapid hemostasis and skin wound healing. ACS Appl. Mater. Inter. 14, 34455–34469 (2022).
Wang, W. D. et al. Injectable self-healing hydrogel via biological environment-adaptive supramolecular assembly for gastric perforation healing. ACS Nano 15, 9913–9923 (2021).
Bi, S. C. et al. Construction of physical-crosslink chitosan/pva double-network hydrogel with surface mineralization for bone repair. Carbohyd. Polym. 224, 115176 (2019).
Zhang, H. J. et al. Tough physical double-network hydrogels based on amphiphilic triblock copolymers. Adv. Mater. 28, 4884–4890 (2016).
Harrington, M. J., Masic, A., Holten-Andersen, N., Waite, J. H. & Fratzl, P. Iron-clad fibers: A metal-based biological strategy for hard flexible coatings. Science 328, 216–220 (2010).
Li, X. et al. Dual ionically cross-linked double-network hydrogels with high strength, toughness, swelling resistance, and improved 3d printing processability. ACS Appl. Mater. Inter. 10, 31198–31207 (2018).
Hu, W. K., Wang, Z. J., Xiao, Y., Zhang, S. M. & Wang, J. L. Advances in crosslinking strategies of biomedical hydrogels. Biomater. Sci. 7, 843–855 (2019).
Deng, Z. X., Wang, H., Ma, P. X. & Guo, B. L. Self-healing conductive hydrogels: preparation, properties and applications. Nanoscale 12, 1224–1246 (2020).
Sijbesma, R. P. et al. Reversible polymers formed from self-complementary monomers using quadruple hydrogen bonding. Science 278, 1601–1604 (1997).
Cui, J. X. & del Campo, A. Multivalent h-bonds for self-healing hydrogels. Chem. Commun. 48, 9302–9304 (2012).
Hou, S., Wang, X. F., Park, S., Jin, X. B. & Ma, P. X. Rapid self-integrating, injectable hydrogel for tissue complex regeneration. Adv. Healthc. Mater. 4, 1491–1495 (2015).
Jeon, I., Cui, J. X., Illeperuma, W. R. K., Aizenberg, J. & Vlassak, J. J. Extremely stretchable and fast self-healing hydrogels. Adv. Mater. 28, 4678–4683 (2016).
Wu, Y. B. et al. Self-healing supramolecular bioelastomers with shape memory property as a multifunctional platform for biomedical applications via modular assembly. Biomaterials 104, 18–31 (2016).
Zhao, J. W., Narita, T. & Creton, C. Dual crosslink hydrogels with metal-ligand coordination bonds: tunable dynamics and mechanics under large deformation. In Self-Healing and Self-Recovering Hydrogels. Advances in Polymer Science, 285 (eds Creton, C. & Okay, O.) (Springer, 2020).
Liang, Y. Q., Li, Z. L., Huang, Y., Yu, R. & Guo, B. L. Dual-dynamic-bond cross-linked antibacterial adhesive hydrogel sealants with on-demand removability for post-wound-closure and infected wound healing. ACS Nano 15, 7078–7093 (2021).
Yang, Y. et al. Antibacterial conductive uv-blocking adhesion hydrogel dressing with mild on-demand removability accelerated drug-resistant bacteria-infected wound healing. ACS Appl. Mater. Inter. 14, 41726–41741 (2022).
Liang, Y. et al. Ph/glucose dual responsive metformin release hydrogel dressings with adhesion and self-healing via dual-dynamic bonding for athletic diabetic foot wound healing. ACS Nano 16, 3194–3207 (2022).
Aleemardani, M., Trikić, M. Z., Green, N. H. & Claeyssens, F. Elastomeric, bioadhesive and ph-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol. Biomater. Sci. 10, 7015–7031 (2022).
Song, F. et al. Chitosan-based multifunctional flexible hemostatic bio-hydrogel. Acta Biomater. 136, 170–183 (2021).
Chen, K., Wu, Z., Liu, Y., Yuan, Y. & Liu, C. Injectable double-crosslinked adhesive hydrogels with high mechanical resilience and effective energy dissipation for joint wound treatment. Adv. Funct. Mater. 32, 2109687 (2022).
Panwar, A., Sk, M. M., Lee, B. H. & Tan, L. P. Synthesis and fabrication of gelatin-based elastomeric hydrogels through cosolvent-induced polymer restructuring. RSC Adv. 12, 7922–7934 (2022).
Balavigneswaran, C. K. & Muthuvijayan, V. Nanohybrid-reinforced gelatin-ureidopyrimidinone-based self-healing injectable hydrogels for tissue engineering applications. ACS Appl. Bio. Mater. 4, 5362–5377 (2021).
Ran, P. et al. On-demand changeable theranostic hydrogels and visual imaging-guided antibacterial photodynamic therapy to promote wound healing. ACS Appl. Mater. Inter. 14, 49375–49388 (2022).
Wu, H. et al. Supramolecular engineering of nacre-inspired bio-based nanocomposite coatings with exceptional ductility and high-efficient self-repair ability. Chem. Eng. J. 437, 135405 (2022).
Liang, Y., Xu, H., Li, Z., Zhangji, A. & Guo, B. Bioinspired injectable self-healing hydrogel sealant with fault-tolerant and repeated thermo-responsive adhesion for sutureless post-wound-closure and wound healing. Nanomicro Lett. 14, 185 (2022).
Yu, R. et al. Supramolecular thermo-contracting adhesive hydrogel with self-removability simultaneously enhancing noninvasive wound closure and mrsa-infected wound healing. Adv. Healthc. Mater. 11, 2102749 (2022).
Yu, R., Li, Z., Pan, G. & Guo, B. Antibacterial conductive self-healable supramolecular hydrogel dressing for infected motional wound healing. Sci. China Chem. 65, 2238–2251 (2022).
Park, J. et al. Biobased stimuli-responsive hydrogels that comprise supramolecular interpenetrating networks and exhibit programmed behaviors. Chem. Mater. 33, 8124–8132 (2021).
Yu, J. et al. An ultrasoft self-fused supramolecular polymer hydrogel for completely preventing postoperative tissue adhesion. Adv. Mater. 33, 2008395 (2021).
Yang, Y. et al. H-bonding supramolecular hydrogels with promising mechanical strength and shape memory properties for postoperative antiadhesion application. ACS Appl. Mater. Inter. 12, 34161–34169 (2020).
Fan, Q. et al. Self-healing nanocomposite hydrogels via janus nanosheets: Multiple effects of metal–coordination and host–guest interactions. React. Funct. Polym. 165, 104963 (2021).
Dong, X. et al. Facile preparation of a thermosensitive and antibiofouling physically crosslinked hydrogel/powder for wound healing. J. Mater. Chem. B 10, 2215–2229 (2022).
Ma, X., Wang, C., Yuan, W., Xie, X. & Song, Y. Highly adhesive, conductive, and self-healing hydrogel with triple cross-linking inspired by mussel and DNA for wound adhesion and human motion sensing. ACS Appl. Polym. Mater. 3, 6586–6597 (2021).
Mehdizadeh, M., Weng, H., Gyawali, D., Tang, L. & Yang, J. Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure. Biomaterials 33, 7972–7983 (2012).
Wei, Z. et al. Novel biocompatible polysaccharide-based self-healing hydrogel. Adv. Funct. Mater. 25, 1352–1359 (2015).
Chen, J. et al. Nanomaterials as photothermal therapeutic agents. Prog. Mater. Sci. 99, 1–26 (2019).
Xu, H. et al. Competition between oxidation and coordination in cross-linking of polystyrene copolymer containing catechol groups. ACS Macro Lett. 1, 457–460 (2012).

Physical dynamic double-network hydrogels as dressings to facilitate tissue repair

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