Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors

Jana Van Dycke, Arno Cuvry, Jan Knickmann, Annelii Ny, Sebastian Rakers, Stefan Taube, Peter de Witte, Johan Neyts, Joana Rocha-Pereira

Published: 2021-04-08 DOI: 10.1038/s41596-021-00499-0

zebrafish larvae

human norovirus

viral replication

small-molecule inhibitors

antiviral efficacy

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Supplementary information

Reporting Summary

Supplementary Video 1

Clipping of the microinjection needle

Supplementary Video 2

Correct size bolus

Supplementary Video 3

Microinjection in the yolk of 3 dpf zebrafish larvae

Supplementary Video 4

Dechorionation of 2 dpf zebrafish larvae

Supplementary Video 5

Microinjection in the pericardial cavity of 3 dpf zebrafish larvae

Fabrication of angstrom-scale two-dimensional channels for mass transport

Efficient and strand-specific profiling of replicating chromatin with enrichment and sequencing of protein-associated nascent DNA in mammalian cells

The eINTACT method for studying nuclear changes in host plant cells targeted by bacterial effectors in native infection contexts

Rapid reaction optimization by robust and economical quantitative benchtop19F NMR spectroscopy

Profiling native pulmonary basement membrane stiffness using atomic force microscopy

Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses

Measuring key human carbohydrate digestive enzyme activities using high-performance anion-exchange chromatography with pulsed amperometric detection

Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures

Preparation, validation and use of a vasoactive tryptophan-derived hydroperoxide and relevant control compounds

Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes

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References

Supplementary information

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Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors

Supplementary information

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