GWAS prioritization analysis

A list of 303 genes (sourced from Nalls et al., 2019 supplementary materials),  containing SNPs at an r²> 0.5 and located within ±1 Mb of 107 common risk variants for sporadic PD was used for prioritization analysis. To convert between human and mouse gene symbols, homologene (v1.4.68.19.3.27, RRID:SCR_002924) and biomaRt (v2.52.0, RRID:SCR_019214) were used. TRAP enrichment (measured as the product of the log­₂ fold-change and FDR-adjusted P value) and specificity indices for DAT-TRAP samples were used for gene prioritization, per lead SNP.