Detect-seq, a chemical labeling and biotin pull-down approach for the unbiased and genome-wide off-target evaluation of programmable cytosine base editors

Zhixin Lei, Haowei Meng, Xichen Rao, Huanan Zhao, Chengqi Yi

Published: 2023-06-04 DOI: 10.1038/s41596-023-00837-4

Cytosine Base Editors

Detect-seq

Off-target Evaluation

Enrichment Strategy

Bioinformatic Pipeline

AI 解读

Supplementary information

Reporting Summary

Supplementary Table 1

Spike-in model sequence and qPCR primer sequence

Supplementary Table 2

An output example for the enrichment significance test results; this file is related to Fig. 4 and Step 51

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Supplementary information

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Detect-seq, a chemical labeling and biotin pull-down approach for the unbiased and genome-wide off-target evaluation of programmable cytosine base editors

Supplementary information

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