An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation inE. coli

Emily J. Geddes, Zhong Li, Paul J. Hergenrother

Published: 2021-09-02 DOI: 10.1038/s41596-021-00598-y

LC-MS/MS assay

intracellular accumulation

eNTRy rules

web-based tool

E. coli

AI 解读

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Novel classes of broad-spectrum antibiotics have been extremely difficult to discover, largely due to the impermeability of the Gram-negative membranes coupled with a poor understanding of the physicochemical properties a compound should possess to promot
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ACKNOWLEDGMENTS

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An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation inE. coli

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