Surgical implantation of wireless, battery-free optoelectronic epidural implants for optogenetic manipulation of spinal cord circuits in mice

Jose G. Grajales-Reyes, Bryan A. Copits, Ferrona Lie, Yongjoon Yu, Raudel Avila, Sherri K. Vogt, Yonggang Huang, Anthony R. Banks, John A. Rogers, Robert W. Gereau, Judith P. Golden

Published: 2021-05-23 DOI: 10.1038/s41596-021-00532-2

Optogenetics

Wireless Optoelectronic Implants

Spinal Cord Circuits

Epidural Space

Neural Circuitry

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Supplementary information

Supplementary Information

Supplementary Methods and Supplementary Figs. 1–6.

Reporting Summary

Supplementary Video 1

Step-by-step demonstration of the surgical implantation procedure for the spinal µLED device.

Fabrication of angstrom-scale two-dimensional channels for mass transport

Efficient and strand-specific profiling of replicating chromatin with enrichment and sequencing of protein-associated nascent DNA in mammalian cells

The eINTACT method for studying nuclear changes in host plant cells targeted by bacterial effectors in native infection contexts

Rapid reaction optimization by robust and economical quantitative benchtop19F NMR spectroscopy

Profiling native pulmonary basement membrane stiffness using atomic force microscopy

Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses

Measuring key human carbohydrate digestive enzyme activities using high-performance anion-exchange chromatography with pulsed amperometric detection

Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures

Preparation, validation and use of a vasoactive tryptophan-derived hydroperoxide and relevant control compounds

Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes

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Supplementary information

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Surgical implantation of wireless, battery-free optoelectronic epidural implants for optogenetic manipulation of spinal cord circuits in mice

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