Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging

Per Svenningsson, Andreas Dannhorn, Richard J. A. Goodwin, Reza Shariatgorji, Anna Nilsson, Elva Fridjonsdottir, Nicole Strittmatter, Luke R. Odell, Per E. Andrén

Published: 2021-06-01 DOI: 10.1038/s41596-021-00538-w

mass spectrometry imaging

neurotransmitter mapping

chemical derivatization

fluoromethylpyridinium

pyrylium reagents

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Molecule-specific techniques such as MALDI and desorption electrospray ionization mass spectrometry imaging enable direct and simultaneous mapping of biomolecules in tissue sections in a single experiment. However, neurotransmitter imaging in the complex
Introduction
Materials
Procedure
Troubleshooting
Timing
Anticipated results
- Reporting Summary
- References
References
ACKNOWLEDGMENTS

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Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging

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