Rapid reaction optimization by robust and economical quantitative benchtop19F NMR spectroscopy

G. Heinrich, M. Kondratiuk, L. J. Gooßen, M. P. Wiesenfeldt

Published: 2024-02-26 DOI: 10.1038/s41596-023-00951-3

benchtop NMR spectroscopy

19F NMR

reaction optimization

fluorine-labeled substrates

processing parameters

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Sections

Figures

References

Introduction
Materials
Procedure 1: general procedure
Procedure 2: Buchwald-Hartwig amination reaction—screening of ligands and bases
- Preparation of the stock solution (indicated reagents, 0.5-mmol scale, 1.5-ml volume per reaction, all multiplied by 10)
- Performing the screening
Procedure 3: Suzuki reaction screening
- Preparation of the stock solution (indicated reagents, 0.5-mmol scale, 1-ml volume per reaction, all multiplied by 6)
- Performing the screening
Procedure 4: C–H arylation screening
- Preparation of the stock solutions (indicated reagents, 0.5-mmol scale, 3-ml volume per reaction, all multiplied by 16.67)
- Performing the screening
Troubleshooting
Timing
Anticipated results
Acknowledgements

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Rapid reaction optimization by robust and economical quantitative benchtop19F NMR spectroscopy

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