An operant social self-administration and choice model in mice

Leslie A. Ramsey, Fernanda M. Holloman, Samantha S. Lee, Marco Venniro

Published: 2023-03-23 DOI: 10.1038/s41596-023-00813-y

Supplementary information

Design file template for partner chamber (Partner chamber.stl). 2. Design file template for partner door (Partner door.stl). 3. Design file template for bedding box (bedding box partner chamber.stl). 4. Design file template for bedding box [modifiable] (bedding box partner chamber.gcode). 5. Design file template for partner chamber door [modifiable] (Door partner chamber 1 box.form). 6. Design file template for Partner chamber door [modifiable] (Door partner chamber 3 box.form).

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Heilig, M., Epstein, D. H., Nader, M. A. & Shaham, Y. Time to connect: bringing social context into addiction neuroscience. Nat. Rev. Neurosci. 17, 592–599 (2016).
Vanderschuren, L. J., Achterberg, E. J. & Trezza, V. The neurobiology of social play and its rewarding value in rats. Neurosci. Biobehav. Rev. 70, 86–105 (2016).
Yizhar, O. & Levy, D. R. The social dilemma: prefrontal control of mammalian sociability. Curr. Opin. Neurobiol. 68, 67–75 (2021).
Panksepp, J. B. & Lahvis, G. P. Social reward among juvenile mice. Genes Brain Behav. 6, 661–671 (2007).
Venniro, M., Banks, M. L., Heilig, M., Epstein, D. H. & Shaham, Y. Improving translation of animal models of addiction and relapse by reverse translation. Nat. Rev. Neurosci. 21, 625–643 (2020).
Venniro, M., Russell, T. I., Zhang, M. & Shaham, Y. Operant social reward decreases incubation of heroin craving in male and female rats. Biol. Psychiatry 86, 848–856 (2019).
Venniro, M. & Shaham, Y. An operant social self-administration and choice model in rats. Nat. Protoc. 15, 1542–1559 (2020).
Venniro, M. et al. Volitional social interaction prevents drug addiction in rat models. Nat. Neurosci. 21, 1520–1529 (2018).
Venniro, M., Panlilio, L. V., Epstein, D. H. & Shaham, Y. The protective effect of operant social reward on cocaine self-administration, choice, and relapse is dependent on delay and effort for the social reward. Neuropsychopharmacology https://doi.org/10.1038/s41386-021-01148-6 (2021).
Venniro, M. et al. Abstinence-dependent dissociable central amygdala microcircuits control drug craving. Proc. Natl Acad. Sci. USA 117, 8126–8134 (2020).
Ellenbroek, B. & Youn, J. Rodent models in neuroscience research: is it a rat race? Dis. Model Mech. 9, 1079–1087 (2016).
Dolen, G., Darvishzadeh, A., Huang, K. W. & Malenka, R. C. Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature 501, 179–184 (2013).
Felix-Ortiz, A. C. & Tye, K. M. Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J. Neurosci. 34, 586–595 (2014).
Gunaydin, L. A. et al. Natural neural projection dynamics underlying social behavior. Cell 157, 1535–1551 (2014).
Levy, D. R. et al. Dynamics of social representation in the mouse prefrontal cortex. Nat. Neurosci. 22, 2013–2022 (2019).
Nardou, R. et al. Oxytocin-dependent reopening of a social reward learning critical period with MDMA. Nature 569, 116–120 (2019).
Wei, D. et al. Endocannabinoid signaling mediates oxytocin-driven social reward. Proc. Natl Acad. Sci. USA 112, 14084–14089 (2015).
Yizhar, O. et al. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477, 171–178 (2011).
Netser, S. et al. Distinct dynamics of social motivation drive differential social behavior in laboratory rat and mouse strains. Nat. Commun. 11, 5908 (2020).
Poole, T. B. & Fish, J. An investigation of playful behaviour in Rattus norvegicus and Mus musculus (Mammalia). J. Zool. Soc. Lond. 175, 61–71 (1975).
Trezza, V., Campolongo, P. & Vanderschuren, L. J. Evaluating the rewarding nature of social interactions in laboratory animals. Dev. Cogn. Neurosci. 1, 444–458 (2011).
Hu, R. K. et al. An amygdala-to-hypothalamus circuit for social reward. Nat. Neurosci. https://doi.org/10.1038/s41593-021-00828-2 (2021).
Martin, L. & Iceberg, E. Quantifying social motivation in mice using operant conditioning. J. Vis. Exp. https://doi.org/10.3791/53009 (2015).
Brodkin, E. S., Hagemann, A., Nemetski, S. M. & Silver, L. M. Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice. Brain Res. 1002, 151–157 (2004).
Panksepp, J. B. et al. Affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice. PLoS ONE 2, e351 (2007).
Golden, S. A. et al. Compulsive addiction-like aggressive behavior in mice. Biol. Psychiatry 82, 239–248 (2017).
Golden, S. A. et al. Nucleus accumbens Drd1-expressing neurons control aggression self-administration and aggression seeking in mice. J. Neurosci. 39, 2482–2496 (2019).
Aleyasin, H. et al. Cell-type-specific role of DeltaFosB in nucleus accumbens in modulating intermale aggression. J. Neurosci. 38, 5913–5924 (2018).
Ramsey, L. A., Holloman, F. M., Hope, B. T., Shaham, Y. & Venniro, M. Waving through the window: A model of volitional social interaction in female mice. Biol. Psychiatry https://doi.org/10.1016/j.biopsych.2021.10.023 (2022).
Miczek, K. A., Maxson, S. C., Fish, E. W. & Faccidomo, S. Aggressive behavioral phenotypes in mice. Behav. Brain Res. 125, 167–181 (2001).
Cann, C., Venniro, M., Hope, B. T. & Ramsey, L. A. Parametric investigation of social place preference in adolescent mice. Behav. Neurosci. 134, 435–443 (2020).
Kummer, K. K. et al. Differences in social interaction- vs. cocaine reward in mouse vs. rat. Front. Behav. Neurosci. 8, 363 (2014).
Pierce, R. C., Crawford, C. A., Nonneman, A. J., Mattingly, B. A. & Bardo, M. T. Effect of forebrain dopamine depletion on novelty-induced place preference behavior in rats. Pharmacol. Biochem. Behav. 36, 321–325 (1990).
Joel, D. & McCarthy, M. M. Incorporating sex as a biological variable in neuropsychiatric research: where are we now and where should we be? Neuropsychopharmacology 42, 379–385 (2017).
Beery, A. K. & Zucker, I. Sex bias in neuroscience and biomedical research. Neurosci. Biobehav. Rev. 35, 565–572 (2011).
Hughes, R. N. Sex does matter: comments on the prevalence of male-only investigations of drug effects on rodent behaviour. Behav. Pharmacol. 18, 583–589 (2007).
Golden, S. A. & Shaham, Y. Aggression addiction and relapse: a new frontier in psychiatry. Neuropsychopharmacology 43, 224–225 (2018).
Richardson, N. R. & Roberts, D. C. Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy. J. Neurosci. Methods 66, 1–11 (1996).
Venniro, M., Caprioli, D. & Shaham, Y. Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence. Prog. Brain Res. 224, 25–52 (2016).
Shalev, U., Grimm, J. W. & Shaham, Y. Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol. Rev. 54, 1–42 (2002).
Venniro, M. et al. Factors modulating the incubation of drug and non-drug craving and their clinical implications. Neurosci. Biobehav. Rev. 131, 847–864 (2021).

An operant social self-administration and choice model in mice

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