Spiral volumetric optoacoustic tomography for imaging whole-body biodynamics in small animals

Sandeep Kumar Kalva, Xosé Luís Deán-Ben, Michael Reiss, Daniel Razansky

Published: 2023-05-18 DOI: 10.1038/s41596-023-00834-7

Spiral volumetric optoacoustic tomography

Whole-body imaging

Biodynamics

Preclinical imaging

Optical contrast

AI 解读

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Fast tracking of biological dynamics across multiple murine organs using the currently commercially available whole-body preclinical imaging systems is hindered by their limited contrast, sensitivity and spatial or temporal resolution. Spiral volumetric o
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ACKNOWLEDGMENTS

Kiessling, F. & Pichler, B. J. Small Animal Imaging: Basics and Practical Guide (Springer Science & Business Media, 2010).
Baker, M. The whole picture. Nature 463, 977–979 (2010).
van der Heyden, B., Roden, S., Dok, R., Nuyts, S. & Sterpin, E. Virtual monoenergetic micro-CT imaging in mice with artificial intelligence. Sci. Rep. 12, 2324 (2022).
Shaker, K., Häggmark, I., Reichmann, J., Arsenian-Henriksson, M. & Hertz, H. M. Phase-contrast X-ray tomography resolves the terminal bronchioles in free-breathing mice. Commun. Phys. 4, 1–9 (2021).
Qin, R. et al. Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors. Nat. Commun. 13, 1938 (2022).
Zhan, S. et al. Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth. Br. J. Cancer 127, 1–13 (2022).
Kim, D.-Y. et al. In vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography. Nat. Commun. 13, 1926 (2022).
Li, D. et al. SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 mapping in mice. Acta Pharmacol. Sin. 43, 1–9 (2021).
Zhang, Y. et al. Augmented ultrasonography with implanted CMOS electronic motes. Nat. Commun. 13, 3521 (2022).
Heiles, B. et al. Performance benchmarking of microbubble-localization algorithms for ultrasound localization microscopy. Nat. Biomed. Eng. 6, 605–616 (2022).
Enninful, A., Baysoy, A. & Fan, R. Unmixing for ultra-high-plex fluorescence imaging. Nat. Commun. 13, 3473 (2022).
Glaser, A. K. et al. A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues. Nat. Methods 19, 613–619 (2022).
Bouchard, M. B. et al. Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms. Nat. Photon. 9, 113–119 (2015).
Santos‐Coquillat, A. et al. Goat milk exosomes as natural nanoparticles for detecting inflammatory processes by optical imaging. Small 18, 2105421 (2022).
Beard, P. Biomedical photoacoustic imaging. Interface Focus 1, 602–631 (2011).
Manohar, S. & Razansky, D. Photoacoustics: a historical review. Adv. Opt. Photonics 8, 586–617 (2016).
Das, D., Sharma, A., Rajendran, P. & Pramanik, M. Another decade of photoacoustic imaging. Phys. Med. Biol. 66, 05TR01 (2021).
Deán-Ben, X. L., Gottschalk, S., Mc Larney, B., Shoham, S. & Razansky, D. Advanced optoacoustic methods for multiscale imaging of in vivo dynamics. Chem. Soc. Rev. 46, 2158–2198 (2017).
Deán‐Ben, X. L. & Razansky, D. Optoacoustic imaging of the skin. Exp. Dermatol. 30, 1598–1609 (2021).
Wang, L. V. & Hu, S. Photoacoustic tomography: in vivo imaging from organelles to organs. Science 335, 1458–1462 (2012).
Kruger, R. A., Kiser, W. L. Jr, Reinecke, D. R. & Kruger, G. A. Thermoacoustic computed tomography using a conventional linear transducer array. Med. Phys. 30, 856–860 (2003).
Wang, X. et al. Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain. Nat. Biotechnol. 21, 803–806 (2003).
Xia, J. & Wang, L. V. Small-animal whole-body photoacoustic romography: a review. IEEE Trans. Biomed. Eng. 61, 1380–1389 (2014).
Jeon, M., Kim, J. & Kim, C. Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo. Med. Biol. Eng. Comput. 54, 283–294 (2016).
Ma, R., Taruttis, A., Ntziachristos, V. & Razansky, D. Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging. Opt. Express 17, 21414–21426 (2009).
Gateau, J., Caballero, M. Á. A., Dima, A. & Ntziachristos, V. Three‐dimensional optoacoustic tomography using a conventional ultrasound linear detector array: whole‐body tomographic system for small animals. Med. Phys. 40, 013302 (2013).
Brecht, H.-P. F. et al. Whole-body three-dimensional optoacoustic tomography system for small animals. J. Biomed. Opt. 14, 064007 (2009).
Xia, J. et al. Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo. J. Biomed. Opt. 17, 050506 (2012).
Razansky, D., Buehler, A. & Ntziachristos, V. Volumetric real-time multispectral optoacoustic tomography of biomarkers. Nat. Protoc. 6, 1121–1129 (2011).
Lv, J. et al. Hemispherical photoacoustic imaging of myocardial infarction: in vivo detection and monitoring. Eur. Radiol. 28, 2176–2183 (2018).
Gottschalk, S. et al. Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain. Nat. Biomed. Eng. 3, 392–401 (2019).
Gottschalk, S., Felix Fehm, T., Luís Deán-Ben, X. & Razansky, D. Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography. J. Cerebr. Blood Flow. Metab. 35, 531–535 (2015).
Fehm, T. F., Deán-Ben, X. L., Ford, S. J. & Razansky, D. In vivo whole-body optoacoustic scanner with real-time volumetric imaging capacity. Optica 3, 1153–1159 (2016).
Deán-Ben, X. L., Fehm, T. F., Ford, S. J., Gottschalk, S. & Razansky, D. Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice. Light Sci. Appl. 6, e16247 (2017).
Ron, A., Kalva, S. K., Periyasamy, V., Deán‐Ben, X. L. & Razansky, D. Flash scanning volumetric optoacoustic tomography for high resolution whole‐body tracking of nanoagent kinetics and biodistribution. Laser Photonics Rev. 15, 2000484 (2021).
Kalva, S. K., Dean-Ben, X. L. & Razansky, D. Single-sweep volumetric optoacoustic tomography of whole mice. Photonics Res. 9, 899–908 (2021).
Kalva, S. K., Sánchez-Iglesias, A., Deán-Ben, X. L., Liz-Marzán, L. M. & Razansky, D. Rapid volumetric optoacoustic tracking of nanoparticle kinetics across murine organs. ACS Appl. Mater. Interfaces 4, 172–178 (2021).
Ron, A., Deán-Ben, X. L., Gottschalk, S. & Razansky, D. Volumetric optoacoustic imaging unveils high-resolution patterns of acute and cyclic hypoxia in a murine model of breast cancer. Cancer Res. 79, 4767–4775 (2019).
Ivankovic, I. et al. Volumetric optoacoustic tomography enables non-invasive in vivo characterization of impaired heart function in hypoxic conditions. Sci. Rep. 9, 8369 (2019).
Berghen, N. et al. Radiosafe micro-computed tomography for longitudinal evaluation of murine disease models. Sci. Rep. 9, 17598 (2019).
Chen, X. et al. Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus. Nat. Commun. 10, 5239 (2019).
Zhang, P. et al. A review of advances in imaging methodology in fluorescence molecular tomography. Phys. Med. Biol. 67, 10TR01 (2022).
Ntziachristos, V., Ripoll, J., Wang, L. V. & Weissleder, R. Looking and listening to light: the evolution of whole-body photonic imaging. Nat. Biotechnol. 23, 313–320 (2005).
Patwardhan, S. V., Bloch, S. R., Achilefu, S. & Culver, J. P. Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice. Opt. Express 13, 2564–2577 (2005).
Hu, P., Li, L., Lin, L. & Wang, L. V. Spatiotemporal antialiasing in photoacoustic computed tomography. IEEE Trans. Med. Imaging 39, 3535–3547 (2020).
Rockwell, B., Thomas, R. & Zimmerman, S. in International Laser Safety Conference. 75–77 (Laser Institute of America, 2015).
Dean-Ben, X. L. & Razansky, D. Portable spherical array probe for volumetric real-time optoacoustic imaging at centimeter-scale depths. Opt. Express 21, 28062–28071 (2013).
Dean-Ben, X. L., Ozbek, A. & Razansky, D. Volumetric real-time tracking of peripheral human vasculature with GPU-accelerated three-dimensional optoacoustic tomography. IEEE Trans. Med. Imaging 32, 2050–2055 (2013).
Deán-Ben, X. L., Özbek, A. & Razansky, D. Accounting for speed of sound variations in volumetric hand-held optoacoustic imaging. Front. Optoelectron. 10, 280–286 (2017).
Szabo, T. L. Diagnostic Ultrasound Imaging: Inside Out (Academic Press, 2004).
Ron, A., Davoudi, N., Deán-Ben, X. L. & Razansky, D. Self-gated respiratory motion rejection for optoacoustic tomography. Appl. Sci. 9, 2737 (2019).
Dean-Ben, X. L., Ford, S. J. & Razansky, D. High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion. Sci. Rep. 5, 10133 (2015).
Merčep, E., Burton, N. C., Claussen, J. & Razansky, D. Whole-body live mouse imaging by hybrid reflection-mode ultrasound and optoacoustic tomography. Opt. Lett. 40, 4643–4646 (2015).
Lutzweiler, C. & Razansky, D. Optoacoustic imaging and tomography: reconstruction approaches and outstanding challenges in image performance and quantification. Sensors 13, 7345–7384 (2013).
Chen, Z. et al. Simultaneous functional magnetic resonance and optoacoustic imaging of brain‐wide sensory responses in mice. Adv. Sci. 10, e2205191 (2022).
Lin, H.-C. A. et al. Characterization of cardiac dynamics in an acute myocardial infarction model by four-dimensional optoacoustic and magnetic resonance imaging. Theranostics 7, 4470 (2017).

Spiral volumetric optoacoustic tomography for imaging whole-body biodynamics in small animals

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