Genetic in vivo engineering of human T lymphocytes in mouse models

Tatjana Weidner, Shiwani Agarwal, Séverine Perian, Floriane Fusil, Gundula Braun, Jessica Hartmann, Els Verhoeyen, Christian J. Buchholz

Published: 2021-04-11 DOI: 10.1038/s41596-021-00510-8

Gene delivery

Humanized mouse

Lentiviral vector

T lymphocytes

Chimeric antigen receptors

AI 解读

Purification of infection-associated macropinosomes by magnetic isolation for proteomic characterization

Hi-CO: 3D genome structure analysis with nucleosome resolution

Practical and concise synthesis of nucleoside analogs

Comprehensive analysis of glycosphingolipid glycans by lectin microarrays and MALDI-TOF mass spectrometry

Human primordial germ cell-like cells specified from resetting precursors develop in human hindgut organoids

KAS-seq: genome-wide sequencing of single-stranded DNA by N3-kethoxal–assisted labeling

Detecting chromosomal interactions in Capture Hi-C data with CHiCAGO and companion tools

Capture of the newly transcribed RNA interactome using click chemistry

Design, assembly, and characterization of membrane-spanning DNA nanopores

Transcriptome-wide identification of RNA-binding protein binding sites using seCLIP-seq

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Receptor targeting of vector particles is a key technology to enable cell type–nobreakspecific invivo gene delivery. For example, Tcells in humanized mouse models can be modified by lentiviral vectors (LVs) targeted to human T-cell markers to en
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ACKNOWLEDGMENTS

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Genetic in vivo engineering of human T lymphocytes in mouse models

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