Design and application of the transformer base editor in mammalian cells and mice

Wenyan Han, Bao-Qing Gao, Junjie Zhu, Zongxing He, Jianfeng Li, Li Yang, Jia Chen

Published: 2023-10-03 DOI: 10.1038/s41596-023-00877-w

mammalian cells

base editing

transformer base editor

off-target mutations

gene editing

AI 解读

Deoxyfluorination of phenols for chemoselective18F-labeling of peptides

Stable isotope tracing to assess tumor metabolism in vivo

Measuring DNA modifications with the comet assay: a compendium of protocols

Detect-seq, a chemical labeling and biotin pull-down approach for the unbiased and genome-wide off-target evaluation of programmable cytosine base editors

A systems-level mass spectrometry-based technique for accurate and sensitive quantification of the RNA cap epitranscriptome

Spooling electrochemiluminescence spectroscopy: development, applications and beyond

Chronic, cortex-wide imaging of specific cell populations during behavior

Chromatin accessibility profiling by ATAC-seq

Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture

Pooled genetic perturbation screens with image-based phenotypes

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References

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Design and application of the transformer base editor in mammalian cells and mice

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