Click chemistry: a transformative technology in nuclear medicine

Samantha M. Sarrett, Brian M. Zeglis, David Bauer, Jason S. Lewis

Published: 2023-04-25 DOI: 10.1038/s41596-023-00825-8

click chemistry

nuclear medicine

radiopharmaceutical chemistry

azide-alkyne cycloaddition

copper-catalyzed reaction

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Extraction of nuclei from archived postmortem tissues for single-nucleus sequencing applications

High-quality and robust protein quantification in large clinical/pharmaceutical cohorts with IonStar proteomics investigation

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Experimental modulation of physiological force application on leg joint neurons in intactDrosophila melanogaster

Combining surface-accessible Ag and Au colloidal nanomaterials with SERS for in situ analysis of molecule–metal interactions in complex solution environments

Generation of mouse–human chimeric embryos

Labeling and tracking of immune cells in ex vivo human skin

Large-scale preparation of fluorescence multiplex host cell reactivation (FM-HCR) reporters

Mutate-and-chemical-shift-fingerprint (MCSF) to characterize excited states in RNA using NMR spectroscopy

Comprehensive multi-attribute method workflow for biotherapeutic characterization and current good manufacturing practices testing

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The 2022 Nobel Prize in Chemistry was awarded to Professors K. Barry Sharpless, Morten Meldal and Carolyn Bertozzi for their pioneering roles in the advent of click chemistry. Sharpless and Meldal worked to develop the canonical click reaction—the copper-
The CuAAC reaction
The SPAAC reaction
‘Next-generation’ click reactions
- Outlook
References
ACKNOWLEDGMENTS

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Click chemistry: a transformative technology in nuclear medicine

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