Rolling circle amplification (RCA)-based DNA hydrogel

Rui Zhang, Jianpu Tang, Dayong Yang, Chi Yao

Published: 2021-10-28 DOI: 10.1038/s41596-021-00621-2

DNA hydrogel

Rolling circle amplification

3D hydrogel network

Bone marrow mesenchymal stem cells

Cell delivery

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Supplementary information

Reporting Summary

Supplementary Data 1

CAD file for 3D printing design

Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS

Dual detection of chromatin accessibility and DNA methylation using ATAC-Me

Single-particle tracking photoactivated localization microscopy of membrane proteins in living plant tissues

Design and simulation of DNA, RNA and hybrid protein–nucleic acid nanostructures with oxView

Stabilization and structure determination of integral membrane proteins by termini restraining

Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds

Design, assembly, and characterization of membrane-spanning DNA nanopores

Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance

Analysis framework and experimental design for evaluating synergy-driving gene expression

Medulloblastoma and high-grade glioma organoids for drug screening, lineage tracing, co-culture and in vivo assay

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Yuk, H., Lu, B. & Zhao, X. Hydrogel bioelectronics. Chem. Soc. Rev. 48, 1642–1667 (2019).
Zhang, Y. S. & Khademhosseini, A. Advances in engineering hydrogels. Science 356, eaaf3627 (2017).
Bao, M., Xie, J. & Huck, W. T. S. Recent advances in engineering the stem cell microniche in 3D. Adv. Sci. 5, 1800448 (2018).
Chaudhuri, O. et al. Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat. Mater. 15, 326–334 (2016).
Kraehenbuehl, T. P., Langer, R. & Ferreira, L. S. Three-dimensional biomaterials for the study of human pluripotent stem cells. Nat. Methods 8, 731–736 (2011).
Baker, B. M. et al. Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments. Nat. Mater. 14, 1262–1268 (2015).
Culver, H. R., Clegg, J. R. & Peppas, N. A. Analyte-responsive hydrogels: Intelligent materials for biosensing and drug delivery. Acc. Chem. Res. 50, 170–178 (2017).
Seeman, N. C. Nucleic acid junctions and lattices. J. Theor. Biol. 99, 237–247 (1982).
Yang, D. et al. DNA materials: bridging nanotechnology and biotechnology. Acc. Chem. Res. 47, 1902–1911 (2014).
Roh, Y. H., Ruiz, R. C., Peng, S., Lee, J. B. & Luo, D. Engineering DNA-based functional materials. Chem. Soc. Rev. 40, 5730–5744 (2011).
Wang, D., Hu, Y., Liu, P. & Luo, D. Bioresponsive DNA hydrogels: beyond the conventional stimuli responsiveness. Acc. Chem. Res. 50, 733–739 (2017).
Shao, Y., Jia, H., Cao, T. & Liu, D. Supramolecular hydrogels based on DNA self-assembly. Acc. Chem. Res. 50, 659–668 (2017).
Kahn, J. S., Hu, Y. & Willner, I. Stimuli-responsive DNA-based hydrogels: from basic principles to applications. Acc. Chem. Res. 50, 680–690 (2017).
Li, J. et al. Self-assembly of DNA nanohydrogels with controllable size and stimuli-responsive property for targeted gene regulation therapy. J. Am. Chem. Soc. 137, 1412–1415 (2015).
Wang, J. et al. Clamped hybridization chain reactions for the self-assembly of patterned DNA hydrogels. Angew. Chem. Int. Ed. 56, 2171–2175 (2017).
Nöll, T. et al. Construction of three-dimensional DNA hydrogels from linear building blocks. Angew. Chem. Int. Ed. 53, 8328–8332 (2014).
Li, J. et al. Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications. Chem. Soc. Rev. 45, 1410–1431 (2016).
English, M. A. et al. Programmable crispr-responsive smart materials. Science 365, 780–785 (2019).
Li, F., Tang, J., Geng, J., Luo, D. & Yang, D. Polymeric DNA hydrogel: Design, synthesis and applications. Prog. Polym. Sci. 98, 101163 (2019).
Um, S. H. et al. Enzyme-catalysed assembly of DNA hydrogel. Nat. Mater. 5, 797–801 (2006).
Cheng, E. et al. A pH-triggered, fast-responding DNA hydrogel. Angew. Chem. Int. Ed. 48, 7660–7663 (2009).
Lee, J. B. et al. A mechanical metamaterial made from a DNA hydrogel. Nat. Nanotechnol. 7, 816–820 (2012).
Yao, C. et al. Double rolling circle amplification generates physically cross-linked DNA network for stem cell fishing. J. Am. Chem. Soc. 142, 3422–3429 (2020).
Tang, J. et al. Super-soft and super-elastic DNA robot with magnetically-driven navigational locomotion for cell delivery in confined space. Angew. Chem. Int. Ed. 59, 2490–2495 (2020).
Geng, J. et al. A fluorescent biofunctional DNA hydrogel prepared by enzymatic polymerization. Adv. Healthc. Mater. 7, 1700998 (2018).
Merindol, R., Delechiave, G., Heinen, L., Catalani, L. H. & Walther, A. Modular design of programmable mechanofluorescent DNA hydrogels. Nat. Commun. 10, 528 (2019).
Hamada, S. et al. Dynamic DNA material with emergent locomotion behavior powered by artificial metabolism. Sci. Robot. 4, eaaw3512 (2019).
Madl, C. M., Heilshorn, S. C. & Blau, H. M. Bioengineering strategies to accelerate stem cell therapeutics. Nature 557, 335–342 (2018).
De Luca, M. et al. Advances in stem cell research and therapeutic development. Nat. Cell Biol. 21, 801–811 (2019).
Qian, X. et al. Untethered recyclable tubular actuators with versatile locomotion for soft continuum robots. Adv. Mater., e1801103 (2018).
Wang, C. et al. Soft ultrathin electronics innervated adaptive fully soft robots. Adv. Mater. 30, e1706695 (2018).
Cangialosi, A. et al. DNA sequence-directed shape change of photopatterned hydrogels via high-degree swelling. Science 357, 1126–1130 (2017).
Yang, C. & Suo, Z. Hydrogel ionotronics. Nat. Rev. Mater. 3, 125–142 (2018).
Gao, T. et al. Design and fabrication of flexible DNA polymer cocoons to encapsulate live cells. Nat. Commun. 10, 2946 (2019).
Ye, D. et al. Encapsulation and release of living tumor cells using hydrogels with the hybridization chain reaction. Nat. Protoc. 15, 2163–2185 (2020).
Ellington, A. D. & Szostak, J. W. In vitro selection of RNA molecules that bind specific ligands. Nature 346, 818–822 (1990).
Li, L. et al. Nucleic acid aptamers for molecular diagnostics and therapeutics: Advances and perspectives. Angew. Chem. Int. Ed. Engl. 60, 2221–2231 (2021).
McCarthy, S. A., Davies, G. L. & Gun’ko, Y. K. Preparation of multifunctional nanoparticles and their assemblies. Nat. Protoc. 7, 1677–1693 (2012).

Rolling circle amplification (RCA)-based DNA hydrogel

Supplementary information

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