SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding

Sofia A. Quinodoz, Prashant Bhat, Peter Chovanec, Joanna W. Jachowicz, Noah Ollikainen, Elizabeth Detmar, Elizabeth Soehalim, Mitchell Guttman

Published: 2022-01-09 DOI: 10.1038/s41596-021-00633-y

nucleus

3D interactions

SPRITE

barcode

gene regulation

AI 解读

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A fundamental question in gene regulation is how cell-type-specific gene expression is influenced by the packaging of DNA within the nucleus of each cell. We recently developed Split-Pool Recognition of Interactions by Tag Extension (SPRITE), which enable
Introduction
Materials
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Troubleshooting
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Anticipated results
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ACKNOWLEDGMENTS

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SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding

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