Facile synthesis of per(6-O-tert-butyldimethylsilyl)-α-, β-, and γ-cyclodextrin as protected intermediates for the functionalization of the secondary face of the macrocycles

Gábor Benkovics, Milo Malanga, Giovanna Cutrone, Szabolcs Béni, Antonio Vargas-Berenguel, Juan Manuel Casas-Solvas

Published: 2021-01-14 DOI: 10.1038/s41596-020-00443-8

cyclodextrin derivatives

silylation

secondary face functionalization

column chromatography

high yield synthesis

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Per(6-O-tert-butyldimethylsilyl)-α-, β- and γ-cyclodextrin derivatives are well-known as synthetic intermediates that enable the selective mono-, partial, or perfunctionalization of the secondary face of the macrocycles. Although s
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ACKNOWLEDGMENTS

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Facile synthesis of per(6-O-tert-butyldimethylsilyl)-α-, β-, and γ-cyclodextrin as protected intermediates for the functionalization of the secondary face of the macrocycles

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