A bifunctional molecule-assisted synthesis of mimics for use in probing the ubiquitination system

Qingyun Zheng, Tian Wang, Junxiong Mao, Guochao Chu, Lujun Liang, Yangwode Jing, Chong Zuo, Yuanyuan Yu, Honggang Hu, Man Pan

Published: 2022-11-01 DOI: 10.1038/s41596-022-00761-z

bifunctional molecule

ubiquitination

analog synthesis

chemical ligation

polyubiquitinated samples

AI 解读

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Ubiquitination regulates almost every life process of eukaryotes. The study of the ubiquitin (Ub) coupling or decoupling process and the interaction study of Ub–nobreakUb binding protein have always been the central focus. However, such studies ar
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ACKNOWLEDGMENTS

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A bifunctional molecule-assisted synthesis of mimics for use in probing the ubiquitination system

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